Bicalutamide Drug Information

Contains Bicalutamide drug information and provides Bicalutamide drug indication, contraindication, special concerns, side effects, overdose management and dosage
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In combination therapy with a leutinizing hormone-releasing hormone analog for the treatment of advanced prostate cancer.
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Special Concerns:
Use with caution in clients with moderate to severe hepatic impairment and during lactation. Safety and efficacy have not been established in children.
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Side Effects:
GI: Constipation, N&V, diarrhea, anorexia, dyspepsia, rectal hemorrhage, dry mouth, melena. CNS: Dizziness, paresthesia, insomnia, anxiety, depression, decreased libido, hypertonia, confusion, neuropathy, somnolence, nervousness. GU: Gynecomastia, nocturia, hematuria, UTI, impotence, urinary incontinence, urinary frequency, impaired urination, dysuria, urinary retention, urinary urgency. CV: Hot flashes (most common), hypertension, angina pectoris, CHF. Metabolic: Peripheral edema, hyperglycemia, weight loss or gain, dehydration, gout. Musculoskeletal: Myasthenia, arthritis, myalgia, leg cramps, pathologic fracture. Respiratory: Dyspnea, increased cough, pharyngitis, bronchitis, pneumonia, rhinitis, lung disorder. Dermatologic: Rash, sweating, dry skin, pruritus, alopecia. Hematologic: Anemia, hypochromic and iron deficiency anemia. Body as a whole: General pain, back pain, asthenia, pelvic pain, abdominal pain, chest pain, flu syndrome, edema, neoplasm, fever, neck pain, chills, sepsis. Miscellaneous: Infection, bone pain, headache, breast pain, diabetes mellitus.
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Overdose Management:
No Available information
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Drug Interactions:
Bicalutamide may displace coumarin anticoagulants from their protein-binding sites, resulting in an increased anticoagulant effect.
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•Tablets Prostatic carcinoma.

50 mg (1 tablet) once daily (morning or evening) in combination with an LHRH analog with or without food.
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