Doxepin hydrochloride[ (Adapin, Sinequan) ] Drug Information

Contains Doxepin hydrochloride drug information and provides Doxepin hydrochloride drug indication, contraindication, special concerns, side effects, overdose management and dosage
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Psychoneurotic clients with depression or anxiety. Depression or anxiety due to organic disease or alcoholism. Psychotic depressive disorders with associated anxiety, including involutional depression and manic-depressive disorders. Depression or anxiety associated with organic disease. PUD. Dermatologic disorders including chronic urticaria, angioedema, and nocturnal pruritus due to atopic eczema.
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Use in children less than 12 years of age. Glaucoma or a tendency for urinary retention.
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Special Concerns:
Safety has not been determined in pregnancy.
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Side Effects:
Doxepin has a high incidence of side effects, including a high degree of sedation, decreased libido, extrapyramidal symptoms, dermatitis, pruritus, fatigue, weight gain, edema, paresthesia, breast engorgement, insomnia, tremor, chills, tinnitus, and photophobia.
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Overdose Management:
No Available information
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Drug Interactions:
No Available information
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Capsules, Oral Concentrate Antidepressant, mild to moderate anxiety or depression.

Adults, initial: 25 mg t.i.d. (or up to 150 mg can be given at bedtime); then, adjust dosage to individual response (usual optimum dosage: 75-150 mg/day). Geriatric clients, initially: 25-50 mg/day; dose can be increased as needed and tolerated.

Severe symptoms.

Initial: 50 mg t.i.d.; then, gradually increase to 300 mg/day.

Emotional symptoms with organic disease.

25-50 mg/day.


10-30 mg at bedtime.

Cream 5%

Apply a thin film q.i.d. with at least a 3-4 hr interval between applications.
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