Gabapentin[ (Neurontin) ] Drug Information

Contains Gabapentin drug information and provides Gabapentin drug indication, contraindication, special concerns, side effects, overdose management and dosage
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List of Contents:
  • Indications
  • Contraindications
  • Special Concerns
  • Side Effects
  • Overdose Management
  • Dosage

  • Indications:
    In adults as an adjunct in the treatment of partial seizures with and without secondary generalization. Investigational: Control pain in diabetic neuropathy and shingles.
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    Contraindications:
    No Available information
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    Special Concerns:
    Use during lactation only if benefits outweigh risks. Plasma clearance is reduced in geriatric clients and in those with impaired renal function. Safety and efficacy have not been determined in children less than 12 years of age.
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    Side Effects:
    Side effects listed are those with an incidence of 0.1% or greater.

    CNS: Most commonly: somnolence, ataxia, dizziness, and fatigue. Also, nystagmus, tremor, nervousness, dysarthria, amnesia, depression, abnormal thinking, twitching, abnormal coordination, headache, convulsions (including the possibility of precipitation of status epilepticus) confusion, insomnia, emotional lability, vertigo, hyperkinesia, paresthesia, decreased/increased/absent reflexes, anxiety, hostility, CNS tumors, syncope, abnormal dreaming, aphasia, hypesthesia, intracranial hemorrhage hypotonia, dysesthesia, paresis, dystonia, hemiplegia, facial paralysis, stupor, cerebellar dysfunction, positive Babinski sign, decreased position sense, subdural hematoma, apathy, hallucinations, decreased or loss of libido, agitation depersonalization, euphoria, ``doped-up'' sensation, suicidal tendencies psychoses. GI: Most commonly: N&V. Also, dyspepsia, dry mouth and throat, constipation, dental abnormalities, increased appetite, abdominal pain, diarrhea, anorexia, flatulence, gingivitis, glossitis, gum hemorrhage, thirst, stomatitis, taste loss, unusual taste, increased salivation, gastroenteritis, hemorrhoids, bloody stools, fecal incontinence, hepatomegaly. CV: Hypertension, vasodilation, hypotension, angina pectoris, peripheral vascular disorder, palpitation, tachycardia, migraine, murmur. Musculoskeletal: Myalgia, fracture, tendinitis, arthritis, joint stiffness or swelling, positive Romberg test. Respiratory: Rhinitis, pharyngitis, coughing, pneumonia, epistaxis, dyspnea, apnea. Dermatologic: Pruritus, abrasion, rash, acne, alopecia, eczema, dry skin, increased sweating, urticaria, hirsutism, seborrhea, cyst, herpes simplex. Body as a whole: Weight increase, back pain, peripheral edema, asthenia, facial edema, allergy, weight decrease, chills. GU: Hematuria, dysuria, frequent urination, cystitis, urinary retention, urinary incontinence, vaginal hemorrhage, amenorrhea, dysmenorrhea, menorrhagia, breast cancer, inability to climax, abnormal ejaculation, impotence. Hematologic: Leukopenia, decreased WBCs, purpura, anemia, thrombocytopenia, lymphadenopathy. Ophthalmologic: Diplopia, amblyopia, abnormal vision, cataract, conjunctivitis, dry eyes, eye pain, visual field defect, photophobia, bilateral or unilateral ptosis, eye hemorrhage, hordeolum, eye twitching. Otic: Hearing loss, earache, tinnitus, inner ear infection, otitis, ear fullness.
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    Overdose Management:
    Symptoms: Double vision, slurred speech, drowsiness, lethargy, diarrhea. Treatment: Hemodialysis.
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    Drug Interactions:
    Antacids / Bioavailability of gabapentin Cimetidine / Renal excretion of gabapentin
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    Dosage:
    Capsules Anticonvulsant.

    Adults: Dose range of 900-1,800 mg/day in three divided doses. Titration to an effective dose can begin on day 1 with 300 mg followed by 300 mg b.i.d. on day 2 and 300 mg t.i.d. on day 3. If necessary, the dose may be increased to 300-400 mg t.i.d., up to 1,800 mg/day. In clients with a CCR of 30-60 mL/min, the dose is 300 mg b.i.d.; if the CCR is 15-30 mL/min, the dose is 300 mg/day; if the CCR is less than 15 mL/min, the dose is 300 mg every other day.
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