Griseofulvin[ (Grisactin) ] Drug Information

Contains Griseofulvin drug information and provides Griseofulvin drug indication, contraindication, special concerns, side effects, overdose management and dosage
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List of Contents:
  • Indications
  • Contraindications
  • Special Concerns
  • Side Effects
  • Overdose Management
  • Dosage

  • Indications:
    Tinea (ringworm) infections of skin (including athlete's foot), scalp, groin, and nails. Effective against tinea corporis, tinea pedis, tinea barbae, tinea unguium, tinea cruris, tinea capitis due to Trichophyton species, Microsporum audouinii, M. canis, M. gypseum and Epidermophyton floccosum. It is the only PO drug effective against dermatophytid (tinea ringworm) infections. Not effective against Candida. Establish susceptibility of the infectious agent before treatment is begun.
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    Contraindications:
    Pregnancy. Porphyria or history thereof, hepatocellular failure, and hypersensitivity to drug. Exposure to artificial light or sunlight. Use for infections due to bacteria, candidiasis, actinomycosis, sporotrichosis, tinea versicolor, histoplasmosis, chromoblastomycosis, coccidioidomycosis, cryptococcosis, and North American blastomycosis.
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    Special Concerns:
    Cross sensitivity with penicillin is possible.
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    Side Effects:
    Hypersensitivity: Rashes, urticaria, angioneurotic edema allergic reactions. GI: N&V, diarrhea, epigastric pain, GI bleeding. CNS: Dizziness, headache, confusion, mental fatigue, insomnia. Miscellaneous: Oral thrush, acute intermittent porphyria, paresthesias of extremities after long-term therapy, proteinuria, leukopenia, photosensitivity, worsening of lupus erythematosus, menstrual irregularities, hepatic toxicity, granulocytopenia.
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    Overdose Management:
    No Available information
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    Drug Interactions:
    Alcohol, ethyl / Tachycardia and flushing Anticoagulants, oral / Anticoagulant effect R/T liver breakdown Barbiturates / Effect of griseofulvin R/T GI tract absorption Cyclosporine / Plasma cyclosporine levels pharmacologic effect Oral contraceptives / Oral contraceptive effect breakthrough bleeding, pregnancy, or amenorrhea Salicylates / Serum salicylate levels
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    Dosage:
    Capsules, Oral Suspension, Tablets Tinea corporis, cruris, or capitis.

    Adults: 0.5 g griseofulvin microsize daily in a single dose or divided dose (or 330-375 mg ultramicrosize).

    Tinea pedis or unguium.

    Adults: 0.75-1 g/day of griseofulvin microsize (or 660-750 mg ultramicrosize). After response, decrease dose of microsize to 0.5 g/day. Pediatric, 13.6-22.7 kg: 125-250 mg griseofulvin microsize daily (or 82.5-165 mg ultramicrosize); pediatric, over 22.7 kg: 250-500 mg microsize daily (or 165-330 mg ultramicrosize). NOTE: Dose has not been determined in children less than 2 years of age.
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