Kanamycin sulfate[ (Kantrex) ] Drug Information

Contains Kanamycin sulfate drug information and provides Kanamycin sulfate drug indication, contraindication, special concerns, side effects, overdose management and dosage
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Indications:
Parenteral: Initial therapy for infections due to Escherichia coli, Proteus, Enterobacter aerogenes, Klebsiella pneumoniae, Serratia marcescens and Acinetobacter. May be combined with a penicillin or cephalosporin before knowing results of susceptibility tests. Investigational: As part of a multiple-drug regimen for Mycobacterium avium complex in AIDS clients.

PO: Adjunct to mechanical cleansing of large bowel for suppression of intestinal bacteria; hepatic coma.
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Contraindications:
No Available information
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Special Concerns:
: Use with caution in premature infants and neonates.
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Side Effects:
Sprue-like syndrome with steatorrhea, malabsorption, and electrolyte imbalance.
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Overdose Management:
No Available information
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Drug Interactions:
Procainamide muscle relaxation.
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Dosage:
Capsules Intestinal bacteria suppression.

1 g every hour for 4 hr; then, 1 g q 6 hr for 36-72 hr.

Hepatic coma.

8-12 g/day in divided doses.

IM, IV

Adults and children: 15 mg/kg/day in two to three equal doses. Maximum daily dose should not exceed 1.5 g regardless of route of administration.

For calculating dosage interval (in hr) in clients with impaired renal function, multiply serum creatinine (mg/100 mL) by 9.

IM Tuberculosis.

Adults: 15 mg/kg/day. Not recommended for use in children.

Intraperitoneal

500 mg diluted in 20 mL sterile distilled water.

Inhalation

250 mg in saline--nebulize b.i.d.-q.i.d.

Irrigation of abscess cavities, pleural space, ventricular cavities.

0.25% solution.
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