Levamisole hydrochloride[ (Ergamisol) ] Drug Information

Contains Levamisole hydrochloride drug information and provides Levamisole hydrochloride drug indication, contraindication, special concerns, side effects, overdose management and dosage
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Indications:
In combination with fluorouracil to treat clients with Dukes' stage C colon cancer following surgical resection.
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Contraindications:
Lactation.
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Special Concerns:
Safety and effectiveness have not been demonstrated in children. Agranulocytosis, caused by levamisole, may be accompanied by a flu-like syndrome, or it may be asymptomatic. Thus, hematologic monitoring is required.
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Side Effects:
GI: Commonly nausea and diarrhea; vomiting, stomatitis, anorexia, abdominal pain, constipation, flatulence, dyspepsia. Hematologic: Leukopenia, thrombocytopenia, anemia, granulocytopenia. Dermatologic: Commonly: dermatitis and pruritus; alopecia, skin discoloration. CNS: Dizziness, headache, inability to concentrate, weakness, memory loss, paresthesia, ataxia, somnolence, depression, insomnia, confusion, nervousness, anxiety, forgetfulness. Musculoskeletal: Arthralgia, myalgia. Ophthalmologic: Abnormal tearing, conjunctivitis, blurred vision. Miscellaneous: Fatigue, fever, rigors, chest pain, edema, taste perversion, altered sense of smell, infection, hyperbilirubinemia, epistaxis.
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Overdose Management:
No Available information
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Drug Interactions:
Ethanol / Disulfiram-like reaction when used with levamisole Phenytoin / Phenytoin plasma levels
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Dosage:
•Tablets

Adults, initial: Levamisole, 50 mg q 8 hr for 3 days (starting 7-30 days after surgery) given together with fluorouracil, 450 mg/m2/day by IV push for 5 days (starting 21-34 days after surgery). Maintenance: Levamisole, 50 mg q 8 hr for 3 days q 2 weeks for 1 year; fluorouracil, 450 mg/m2/day by IV push once a week beginning 28 days after the beginning of the 5-day course and continuing for 1 year.
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