Lomefloxacin hydrochloride[ (Maxaquin) ] Drug Information

Contains Lomefloxacin hydrochloride drug information and provides Lomefloxacin hydrochloride drug indication, contraindication, special concerns, side effects, overdose management and dosage
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Indications:
Acute bacterial exacerbation of chronic bronchitis caused by Haemophilus influenzae or Morazella catarrhalis. Uncomplicated UTIs due to Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis or Staphylococcus saprophyticus. Complicated UTIs due to E. coli, K. pneumoniae, P. mirabilis, Pseudomonas aeruginosa, Citrobacter diversus or Enterobacter cloacae. Preoperatively to decrease the incidence of UTIs 3-5 days after surgery in clients undergoing transurethral procedures. Uncomplicated gonococcal infections. Prevent infection in preoperative transrectal prostate biopsy.
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Contraindications:
Use in minor urologic procedures for which prophylaxis is not indicated (e.g., simply cystoscopy, retrograde pyelography). Use for the empiric treatment of acute bacterial exacerbation of chronic bronchitis due to Streptococcus pneumoniae. Lactation.
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Special Concerns:
Plasma clearance is reduced in the elderly. Safety and efficacy have not been determined in children less than 18 years of age. Serious hypersensitivity reactions that are occasionally fatal have occurred, even with the first dose. No dosage adjustment is needed for elderly clients with normal renal function. Not efficiently removed from the body by hemodialysis or peritoneal dialysis.
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Side Effects:
CNS: Confusion, tremor, vertigo, nervousness, anxiety, hyperkinesia, anorexia, agitation, increased appetite, depersonalization, paranoia, coma. GI: GI inflammation or bleeding, dysphagia, tongue discoloration, bad taste in mouth. GU: Dysuria, hematuria, micturition disorder, anuria, strangury, leukorrhea, intermenstrual bleeding perineal pain, vaginal moniliasis, orchitis, epididymitis, proteinuria, albuminuria. Hypersensitivity Reactions: Urticaria, itching, pharyngeal or facial edema, CV collapse tingling, loss of consciousness, dyspnea. CV: Hypotension, tachycardia, bradycardia, extrasystoles, cyanosis, arrhythmia, cardiac failure angina pectoris, MI, pulmonary embolism, cardiomyopathy phlebitis, cerebrovascular disorder. Respiratory: Dyspnea, respiratory infection, epistaxis, bronchospasm cough, increased sputum, respiratory disorder, stridor. Hematologic: Eosinophilia, leukopenia, increase or decrease in platelets, increase in ESR, lymphocytopenia, decreased hemoglobin, anemia, bleeding, increased PT, increase in monocytes. Dermatologic: Urticaria, eczema, skin exfoliation, skin disorder. Ophthalmologic: Conjunctivitis, eye pain. Otic: Earache, tinnitus. Musculoskeletal: Back or chest pain, asthenia, leg cramps, arthralgia, myalgia. Miscellaneous: Increase or decrease in blood glucose, flushing, increased sweating, facial edema, influenza-like symptoms, decreased heat tolerance, purpura, lymphadenopathy, increased fibrinolysis, thirst, gout, hypoglycemia, phototoxicity.
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Overdose Management:
No Available information
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Drug Interactions:
No Available information
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Dosage:
Dosage

•Tablets Acute bacterial exacerbation of chronic bronchitis. Cystitis.

Adults: 400 mg once daily for 10 days.

Complicated UTIs.

Adults: 400 mg once daily for 14 days.

Uncomplicated UTIs.

400 mg once daily for 3 days.

Prophylaxis of infection before surgery for transurethral procedures.

Single 400-mg dose 2-6 hr before surgery.

Uncomplicated gonococcal infections.

400 mg as a single dose (as an alternative to ciprofloxacin or ofloxacin).
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