Losartan potassium and Hydrochlorothiazide[ (Hyzaar) ] Drug Information

Contains Losartan potassium and Hydrochlorothiazide drug information and provides Losartan potassium and Hydrochlorothiazide drug indication, contraindication, special concerns, side effects, overdose management and dosage
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List of Contents:
  • Indications
  • Contraindications
  • Special Concerns
  • Side Effects
  • Overdose Management
  • Dosage

  • Indications:
    Treatment of hypertension. Not indicated for initial therapy. Use the combination of losartan potassium and hydrochlorothiazide when BP is not controlled adequately with losartan potassium alone. Also used for clients whose BP is inadequately controlled by 25 mg/day of hydrochlorothiazide or is controlled but experiences hypokalemia.
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    Contraindications:
    Use in pregnancy, especially during the second and third trimesters. In those with anuria or hypersensitivity to sulfonamide-derived drugs (e.g., hydrochlorothiazide). In severe renal impairment. Lactation.
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    Special Concerns:
    Use with caution in clients with impaired hepatic function or progressive liver disease. Hypersensitivity reactions to hydrochlorothiazide may occur in those with or without a history of allergy or bronchial asthma, although such reactions are more likely in these clients. Thiazides may worsen or activate systemic lupus erythematosus. Safety and efficacy have not been determined in children.
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    Side Effects:
    See individual drug entries
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    Overdose Management:
    No Available information
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    Drug Interactions:
    See individual drug entries.
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    Dosage:
    Tablets Hypertension.

    Adults: One tablet (losartan, 50 mg, and hydrochlorothiazide, 12.5 mg) daily. If BP is not controlled after approximately 3 weeks of therapy, the dose may be increased to 2 tablets daily. The total daily dose should not exceed 2 tablets.
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