Lovastatin (Mevinolin)[ (Mevacor) ] Drug Information

Contains Lovastatin (Mevinolin) drug information and provides Lovastatin (Mevinolin) drug indication, contraindication, special concerns, side effects, overdose management and dosage
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Indications:
As an adjunct to diet in primary hypercholesterolemia (types IIa and IIb) in clients with a significant risk of CAD and who have not responded to diet or other measures. May also be useful in clients with combined hypercholesterolemia and hypertriglyceridemia. To slow the progression of coronary atherosclerosis in clients with CAD in order to lower total and LDL cholesterol levels. Primary prevention of risk of first heart attack, unstable angina, and coronary revascularization procedures in those with average to moderately elevated total cholesterol and LDL-cholesterol and below average HDL-cholesterol. Investigational: Diabetic dyslipidemia, nephrotic hyperlipidemia, familial dysbetalipoproteinemia, and familial combined hyperlipidemia.
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Contraindications:
Use with mibefradil (Posicor).
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Special Concerns:
No Available information
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Side Effects:
CNS: Headache, dizziness, insomnia, paresthesia, insomnia. GI: Flatus (most common), abdominal pain, cramps, diarrhea, constipation, dyspepsia, N&V, heartburn, dysgeusia, acid regurgitation, dry mouth. Musculoskeletal: Myalgia, muscle cramps, pain, arthralgia, leg pain, shoulder pain, localized pain. Miscellaneous: Blurred vision, eye irritation, rash, pruritus, chest pain, alopecia.
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Overdose Management:
No Available information
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Drug Interactions:
Grapefruit juice / Lovastatin plasma levels R/T liver metabolism; risk of myopathy and rhabdomyolysis Isradipine / Clearance of lovastatin
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Dosage:
•Tablets

Adults/adolescents, initial: 20 mg once daily with the evening meal. Initiate at 10 mg/day in clients on immunosuppressants. Dose range: 10-80 mg/day in single or two divided doses, not to exceed 20 mg/day if given with immunosuppressants. Adjust dose at intervals of every 4 weeks, if necessary. If CCR is less than 30 mL/min, use doses greater than 20 mg/day with caution.
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