Metolazone[ (Zaroxolyn) ] Drug Information

Contains Metolazone drug information and provides Metolazone drug indication, contraindication, special concerns, side effects, overdose management and dosage
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Indications:
Slow availability tablets: Edema accompanying CHF; edema accompanying renal diseases, including nephrotic syndrome and conditions of reduced renal function. Alone or in combination with other drugs for the treatment of hypertension.

Rapid availability tablets: Treatment of newly diagnosed mild to moderate hypertension alone or in combination with other drugs. The rapid availability tablets are not to be used to produce diuresis.

Investigational: Alone or as an adjunct to treat calcium nephrolithiasis, premanagement of menstrual syndrome, and adjunct treatment of renal failure.
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Contraindications:
Anuria, prehepatic and hepatic coma, allergy or hypersensitivity to metolazone. Routine use during pregnancy. Lactation.
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Special Concerns:
Use with caution in those with severely impaired renal function. Safety and effectiveness have not been determined in children.
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Side Effects:
The most commonly reported side effects are dizziness, headache, muscle cramps, malaise, lethargy, lassitude, joint pain/swelling, and chest pain.
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Overdose Management:
No Available information
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Drug Interactions:
Alcohol / Hypotensive effect Barbiturates / Hypotensive effect Narcotics / Hypotensive effect NSAIDs / Hypotensive effect of metolazone Salicylates / Hypotensive effect of metolazone
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Dosage:
Slow Availability Tablets Edema due to cardiac failure or renal disease.

Adults: 5-20 mg once daily. For those who experience paroxysmal nocturnal dyspnea, a larger dose may be required to ensure prolonged diuresis and saluresis for a 24-hr period.

Mild to moderate essential hypertension.

Adults: 2.5-5 mg once daily.

Rapid Availability Tablets Mild to moderate essential hypertension.

Adults, initial: 0.5 mg once daily, usually in the morning. If inadequately controlled, the dose may be increased to 1 mg once a day. Increasing the dose higher than 1 mg does not increase the effect.
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