Nilutamide[ (Nilandron) ] Drug Information

Contains Nilutamide drug information and provides Nilutamide drug indication, contraindication, special concerns, side effects, overdose management and dosage
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List of Contents:
  • Indications
  • Contraindications
  • Special Concerns
  • Side Effects
  • Overdose Management
  • Dosage

  • Indications:
    In combination with surgical castration for the treatment of metastatic prostate cancer (stage D2).
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    Contraindications:
    Severe hepatic impairment, severe respiratory insufficiency, hypersensitivity to nilutamide.
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    Special Concerns:
    Many clients experience a delay in adaptation to the dark ranging from seconds to a few minutes. Safety and efficacy have not been determined in children.
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    Side Effects:
    GI: Nausea, constipation, dry mouth, diarrhea, hepatitis, GI disorder, GI hemorrhage melena. CNS: Dizziness, paresthesia, nervousness. CV: Hypertension, heart failure angina, syncope. Respiratory: Interstitial pneumonitis, dyspnea, lung disorder, increased cough, rhinitis. Metabolic/nutritional: Edema, weight loss, intolerance to alcohol. Ophthalmic: Cataract, photophobia, impaired adaptation to dark, abnormal vision. Miscellaneous: Leukopenia, hot flushes, UTI, malaise, pruritus, arthritis, aplastic anemia (rare).
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    Overdose Management:
    No Available information
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    Drug Interactions:
    Phenytoin / Phenytoin metabolism delayed elimination and risk of toxicity Theophylline / Theophylline metabolism delayed elimination and risk of toxicity Vitamin K antagonists / Metabolism of vitamin K antagonists delayed elimination and risk of toxicity
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    Dosage:
    •Tablets Metastatic prostate cancer.

    300 mg (six 50-mg tablets) once daily for 30 days followed by 150 mg (three 50-mg tablets) once daily.
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