Nitrofurantoin[ Macrodantin ] Drug Information

Contains Nitrofurantoin drug information and provides Nitrofurantoin drug indication, contraindication, special concerns, side effects, overdose management and dosage
Search Drugs by Generic or Trade Name:
Browse Drugs by Generic Name:
[ A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z ]

List of Contents:
  • Indications
  • Contraindications
  • Special Concerns
  • Side Effects
  • Overdose Management
  • Dosage

  • Indications:
    UTIs due to susceptible strains of Escherichia coli, Staphylococcus aureus (not for treatment of pyelonephritis or perinephric abscesses), enterococci, and certain strains of Enterobacter and Klebsiella.
    Back to Top
    Anuria, oliguria, and clients with impaired renal function (CCR below 40 mL/min); pregnant women, especially near term; infants less than 1 month of age; and lactation.
    Back to Top
    Special Concerns:
    Use with extreme caution in anemia, diabetes, electrolyte imbalance, avitaminosis B, or a debilitating disease. Safety during lactation has not been established.
    Back to Top
    Side Effects:
    Nitrofurantoin is a potentially toxic drug with many side effects. GI: N&V, anorexia, diarrhea, abdominal pain, parotitis, pancreatitis. CNS: Headache, dizziness, vertigo, drowsiness, nystagmus, confusion, depression, euphoria, psychotic reactions (rare). Hematologic: Leukopenia, thrombocytopenia, eosinophilia, megaloblastic anemia, agranulocytosis granulocytopenia, hemolytic anemia (especially in clients with G6PD deficiency). Allergic: Drug fever, skin rashes, pruritus, urticaria, angioedema, exfoliative dermatitis, erythema multiforme (rarely, Stevens-Johnson syndrome), anaphylaxis arthralgia, myalgia, chills, sialadenitis, asthma symptoms in susceptible clients; maculopapular, erythematous, or eczematous eruption. Pulmonary: Sudden onset of dyspnea, cough, chest pain, fever and chills; pulmonary infiltration with consolidation or pleural effusion on x-ray, elevated ESR, eosinophilia. After subacute or chronic use: dyspnea, nonproductive cough, malaise, interstitial pneumonitis. Permanent impairment of pulmonary function with chronic therapy. A lupus-like syndrome associated with pulmonary reactions. Hepatic: Hepatitis, cholestatic jaundice, chronic active hepatitis, hepatic necrosis (rare). CV: Benign intracranial hypertension, changes in ECG, collapse, cyanosis. Miscellaneous: Peripheral neuropathy, asthenia, alopecia, superinfections of the GU tract, muscle pain.
    Back to Top
    Overdose Management:
    Symptoms: Vomiting (most common). Treatment: Induce emesis. High fluid intake to promote urinary excretion. The drug is dialyzable.
    Back to Top
    Drug Interactions:
    Acetazolamide / Nitrofurantoin effect R/T urine alkalinity produced by acetazolamide Antacids, oral / Nitrofurantoin effect R/T GI tract absorption Anticholinergic drugs / Nitrofurantoin effect R/T stomach absorption Magnesium trisilicate / Nitrofurantoin absorption from GI tract Nalidixic acid / Effect of nalidixic acid Probenecid / High doses secretion of nitrofurantoin toxicity Sodium bicarbonate / Nitrofurantoin effect R/T urine alkalinity produced by sodium bicarbonate
    Back to Top
    Capsules, Oral Suspension UTIs.

    Adults: 50-100 mg q.i.d., not to exceed 600 mg/day. For cystitis, Macrobid is given in doses of 100 mg b.i.d. for 7 days. Pediatric, 1 month of age and over: 5-7 mg/kg/day in four equal doses.

    Prophylaxis of UTIs.

    Adults: 50-100 mg at bedtime. Pediatric, 1 month of age and over: 1 mg/kg/day at bedtime or in two divided doses daily.
    Back to Top
    Most Popular Tags

    nalidixic acid