Pentostatin (2'-deoxycoformycin; DCF)[ (Nipent) ] Drug Information

Contains Pentostatin (2'-deoxycoformycin; DCF) drug information and provides Pentostatin (2'-deoxycoformycin; DCF) drug indication, contraindication, special concerns, side effects, overdose management and dosage
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List of Contents:
  • Indications
  • Contraindications
  • Special Concerns
  • Side Effects
  • Overdose Management
  • Dosage

  • Indications:
    Hairy cell leukemia in adults who are refractory to alpha-interferon; such individuals have progressive disease after a minimum of 3 months of alpha-interferon therapy or no response after a minimum of 6 months of alpha-interferon therapy.
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    Contraindications:
    In combination with fludarabine phosphate. Lactation.
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    Special Concerns:
    Treat clients with infection only if the potential benefit outweighs the risk; infection should be treated before pentostatin therapy is initiated or resumed. Safety and effectiveness have not been determined in children.
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    Side Effects:
    Hematologic: Leukopenia, anemia, thrombocytopenia, ecchymosis, lymphadenopathy, petechia, abnormal erythrocytes, leukocytosis, pancytopenia, purpura, splenomegaly, eosinophilia, hematologic disorder, hemolysis, lymphoma-like reaction. GI: N&V, anorexia, abdominal pain, diarrhea, constipation, flatulence, stomatitis, colitis, dysphagia, dyspepsia, eructation, gastritis, GI hemorrhage gum hemorrhage, intestinal obstruction, leukoplakia, melena, periodontal abscess, proctitis, abnormal stools, esophagitis, gingivitis, mouth disorder. Hepatic: Hepatitis, hepatomegaly, hepatic failure. CNS: Headache, anxiety, abnormal thinking, confusion, depression, dizziness, insomnia, nervousness, paresthesia, somnolence, agitation, amnesia, ataxia, abnormal dreams, depersonalization, emotional lability, hyperesthesia, hypesthesia, hypertonia, incoordination, decreased libido, neuropathy, stupor, tremor, vertigo, coma, seizures. CV: Arrhythmia, abnormal ECG, hemorrhage thrombophlebitis, aortic stenosis, arterial anomaly, cardiomegaly, CHF, cardiac arrest flushing, hypertension, MI palpitation, varicose vein, shock. Dermatologic: Rash, skin disorder, eczema, dry skin, herpes simplex, herpes zoster, maculopapular rash, pruritus, seborrhea, skin discoloration, sweating, vesiculobullous rash, acne, alopecia, exfoliative dermatitis, contact dermatitis, fungal dermatitis, benign skin neoplasm, psoriasis, SC nodule, skin hypertrophy, urticaria. GU: GU disorder, dysuria, hematuria, fibrocystic breasts, gynecomastia, hydronephrosis, oliguria, polyuria, pyuria, toxic nephropathy, urinary frequency, urinary retention, urinary urgency, UTI, impaired urination, urolithiasis, vaginitis. Musculoskeletal: Myalgia, arthralgia, asthenia, facial paralysis, abnormal gait, arthritis, bone pain, osteomyelitis, neck rigidity, pathologic fracture. Respiratory: Cough, URI, lung disorder, bronchitis, dyspnea, epistaxis, lung edema, pneumonia, pharyngitis, rhinitis, sinusitis, asthma, atelectasis, hemoptysis, hyperventilation, hypoventilation, increased sputum, laryngitis, larynx edema, lung fibrosis, pleural effusion, pneumothorax, pulmonary embolus. Body as a whole: Fever, infection, fatigue, weight loss or gain, peripheral edema, pain, allergic reaction, chills, sepsis, chest pain, back pain, flu syndrome, malaise, neoplasm, abscess, enlarged abdomen, ascites, acidosis, dehydration, diabetes mellitus, gout, abnormal healing, cellulitis, facial edema, cyst, fibrosis, granuloma, hernia, hemorrhage or inflammation of the injection site, moniliasis, pelvic pain, photosensitivity, anaphylaxis mucous membrane disorder, immune system disorder, neck pain. Ophthalmic: Abnormal vision, conjunctivitis, eye pain, blepharitis, cataract, diplopia, exophthalmos, lacrimation disorder, optic neuritis, retinal detachment. Miscellaneous: Ear pain, deafness, otitis media, parosmia, taste perversion, tinnitus.
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    Overdose Management:
    Symptoms: Severe renal, hepatic, pulmonary, and CNS toxicity; death can result. Treatment: General supportive measures.
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    Drug Interactions:
    Fludarabine / Risk of fatal pulmonary toxicity Vidarabine / Effect of vidarabine, including side effects
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    Dosage:
    •IV Bolus, IV Infusion Alpha-interferon-refractory hairy cell leukemia.

    4 mg/m2 every other week.
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