Ribavirin and Interferon alfa-2b recombinant[ Rebetron ] Drug Information

Contains Ribavirin and Interferon alfa-2b recombinant drug information and provides Ribavirin and Interferon alfa-2b recombinant drug indication, contraindication, special concerns, side effects, overdose management and dosage
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List of Contents:
  • Indications
  • Contraindications
  • Special Concerns
  • Side Effects
  • Overdose Management
  • Dosage

  • Indications:
    Treatment of chronic hepatitis C in clients with compensated liver disease who either have relapsed following alpha interferon therapy or have previously been untreated with alpha-interferon therapy.
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    Contraindications:
    Pregnancy, in those who may become pregnant, and in male partners of women who are pregnant. Lactation. Hypersensitivity, or history thereof, to alpha interferons and/or ribavirin. Use in clients with autoimmune hepatitis.
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    Special Concerns:
    Use with extreme caution in those with pre-existing psychiatric disorders who report a history of severe depression. Use with caution if CCR is less than 50 mL/min or in pre-existing cardiac disease. Safety and efficacy have not been determined in children less than 18 years of age.
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    Side Effects:
    See individual drugs; selected treatment-emergent side effects follow. Hematologic: Anemia. GI: N&V, anorexia, dyspepsia. CNS: Depression, suicidal behavior, dizziness, insomnia, irritability, emotional lability, impaired concentration, nervousness. Respiratory: Dyspnea, pulmonary infiltrates, pneumonitis, pneumonia, sinusitis. Musculoskeletal: Myalgia, arthralgia, musculoskeletal pain. Dermatologic: Alopecia, rash, pruritus. Body as a whole: Headache, fatigue, rigors, fever, flu-like symptoms, asthenia, chest pain. Miscellaneous: Taste perversion, injection site inflammation or reaction.
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    Overdose Management:
    No Available information
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    Drug Interactions:
    See individual drugs.
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    Dosage:
    Capsules (Rebetol), SC (Intron A) Chronic hepatitis C.

    Adults, 75 kg or less: Rebetol: 2 x 200 mg capsules in the a.m. and 3 x 200 mg capsules in the p.m. Intron A: 3 million I.U. 3 times weekly SC. Adults, more than 75 kg: Rebetol: 3 x 200 mg capsules in the a.m. and 3 x 200 mg capsules in the p.m. Intron A: 3 million I.U. three times a week SC. Reduce the dose of Rebetol by 600 mg daily and Intron A by 1.5 million I.U. three times a week if the hemoglobin is less than 10 g/dL.
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