Sulfasalazine[ Salazopyrin ] Drug Information

Contains Sulfasalazine drug information and provides Sulfasalazine drug indication, contraindication, special concerns, side effects, overdose management and dosage
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List of Contents:
  • Indications
  • Contraindications
  • Special Concerns
  • Side Effects
  • Overdose Management
  • Dosage

  • Indications:
    Ulcerative colitis. Azulfidine EN-tabs are also used to treat rheumatoid arthritis in clients who do not respond well to NSAIDs. Investigational: Ankylosing spondylitis, collagenous colitis, Crohn's disease, psoriasis, juvenile chronic arthritis, psoriatic arthritis.
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    Contraindications:
    Children below 2 years. In persons with marked sulfonamide, salicylate, or related drug hypersensitivity. Intestinal or urinary obstruction.
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    Special Concerns:
    Use with caution during lactation.
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    Side Effects:
    Most common include anorexia, headache, N&V, gastric distress, reversible oligospermia. Less frequently, pruritus, urticaria, fever, Heinz body anemia, hemolytic anemia, cyanosis.
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    Overdose Management:
    No Available information
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    Drug Interactions:
    Digoxin / Absorption of digoxin Folic acid / Absorption of folic acid
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    Dosage:
    •Enteric-Coated Tablets, Tablets Ulcerative colitis.

    Adults, initial: 3-4 g/day in divided doses (1-2 g/day may decrease side effects); maintenance: 500 mg q.i.d. Pediatric, over 2 years of age, initial: 40-60 mg/kg/day in 3 to 6 equally divided doses; maintenance: 30 mg/kg/day in 4 divided doses.

    For desensitization to sulfasalazine.

    Reinstitute at level of 50-250 mg/day; then, give double dose q 4-7 days until desired therapeutic level reached. Do not attempt in those with a history of agranulocytosis or who have experienced anaphylaxis previously with sulfasalazine.

    Collagenous colitis.

    2-3 g/day.

    Psoriasis.

    3-4 g/day.

    Juvenile chronic arthritis.

    50 mg/kg.

    Psoriatic arthritis.

    2 g/day.
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