Sulfasalazine[ Salazopyrin ] Drug Information

Contains Sulfasalazine drug information and provides Sulfasalazine drug indication, contraindication, special concerns, side effects, overdose management and dosage
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Ulcerative colitis. Azulfidine EN-tabs are also used to treat rheumatoid arthritis in clients who do not respond well to NSAIDs. Investigational: Ankylosing spondylitis, collagenous colitis, Crohn's disease, psoriasis, juvenile chronic arthritis, psoriatic arthritis.
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Children below 2 years. In persons with marked sulfonamide, salicylate, or related drug hypersensitivity. Intestinal or urinary obstruction.
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Special Concerns:
Use with caution during lactation.
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Side Effects:
Most common include anorexia, headache, N&V, gastric distress, reversible oligospermia. Less frequently, pruritus, urticaria, fever, Heinz body anemia, hemolytic anemia, cyanosis.
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Overdose Management:
No Available information
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Drug Interactions:
Digoxin / Absorption of digoxin Folic acid / Absorption of folic acid
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•Enteric-Coated Tablets, Tablets Ulcerative colitis.

Adults, initial: 3-4 g/day in divided doses (1-2 g/day may decrease side effects); maintenance: 500 mg q.i.d. Pediatric, over 2 years of age, initial: 40-60 mg/kg/day in 3 to 6 equally divided doses; maintenance: 30 mg/kg/day in 4 divided doses.

For desensitization to sulfasalazine.

Reinstitute at level of 50-250 mg/day; then, give double dose q 4-7 days until desired therapeutic level reached. Do not attempt in those with a history of agranulocytosis or who have experienced anaphylaxis previously with sulfasalazine.

Collagenous colitis.

2-3 g/day.


3-4 g/day.

Juvenile chronic arthritis.

50 mg/kg.

Psoriatic arthritis.

2 g/day.
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