Tolbutamide[ (Orinase) ] Drug Information

Contains Tolbutamide drug information and provides Tolbutamide drug indication, contraindication, special concerns, side effects, overdose management and dosage
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Indications:
Most useful for clients with poor general physical status who should receive a short-acting compound.

Tolbutamide sodium is used to diagnose pancreatic islet cell tumors. It causes blood glucose, in the presence of a tumor, to drop quickly after IV administration and remain low for 3 hr.
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Contraindications:
No Available information
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Special Concerns:
No Available information
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Side Effects:
Melena (dark, bloody stools) in some clients with a history of peptic ulcer. Relapse or secondary failure may occur a few months after therapy has been started. May cause hyponatremia and a mild goiter.
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Overdose Management:
No Available information
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Drug Interactions:
Alcohol / Photosensitivity reactions Sulfinpyrazone / Effect of tolbutamide due to breakdown by liver
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Dosage:
•Tablets Diabetes mellitus.

Adults, initial: 1-2 g/day. Adjust dosage depending on response, up to 3 g/day. Usual maintenance: 0.25-3 g/day. A daily dose greater than 2 g is seldom required.
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