Tolbutamide[ (Orinase) ] Drug Information

Contains Tolbutamide drug information and provides Tolbutamide drug indication, contraindication, special concerns, side effects, overdose management and dosage
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List of Contents:
  • Indications
  • Contraindications
  • Special Concerns
  • Side Effects
  • Overdose Management
  • Dosage

  • Indications:
    Most useful for clients with poor general physical status who should receive a short-acting compound.

    Tolbutamide sodium is used to diagnose pancreatic islet cell tumors. It causes blood glucose, in the presence of a tumor, to drop quickly after IV administration and remain low for 3 hr.
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    Contraindications:
    No Available information
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    Special Concerns:
    No Available information
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    Side Effects:
    Melena (dark, bloody stools) in some clients with a history of peptic ulcer. Relapse or secondary failure may occur a few months after therapy has been started. May cause hyponatremia and a mild goiter.
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    Overdose Management:
    No Available information
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    Drug Interactions:
    Alcohol / Photosensitivity reactions Sulfinpyrazone / Effect of tolbutamide due to breakdown by liver
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    Dosage:
    •Tablets Diabetes mellitus.

    Adults, initial: 1-2 g/day. Adjust dosage depending on response, up to 3 g/day. Usual maintenance: 0.25-3 g/day. A daily dose greater than 2 g is seldom required.
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