Triamterene[ (Dyrenium) ] Drug Information

Contains Triamterene drug information and provides Triamterene drug indication, contraindication, special concerns, side effects, overdose management and dosage
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Edema due to CHF, hepatic cirrhosis, nephrotic syndrome, steroid therapy, secondary hyperaldosteronism, and idiopathic edema. May be used alone or with other diuretics. Investigational: Prophylaxis and treatment of hypokalemia, adjunct in the treatment of hypertension.
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Hypersensitivity to drug, severe or progressive renal insufficiency, severe hepatic disease, anuria, hyperkalemia, hyperuricemia, gout, history of nephrolithiasis. Lactation.
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Special Concerns:
Safety and efficacy have not been determined in children.
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Side Effects:
Electrolyte: Hyperkalemia, electrolyte imbalance. GI: Nausea, vomiting (may also be indicative of electrolyte imbalance), diarrhea, dry mouth. CNS: Dizziness, drowsiness, fatigue, weakness, headache. Hematologic: Megaloblastic anemia, thrombocytopenia. Renal: Azotemia, interstitial nephritis. Miscellaneous: Anaphylaxis photosensitivity, hypokalemia, jaundice, muscle cramps, rash.
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Overdose Management:
Symptoms: Electrolyte imbalance, especially hyperkalemia. Also, nausea, vomiting, other GI disturbances, weakness, hypotension, reversible acute renal failure. Treatment: Immediately induce vomiting or perform gastric lavage. Evaluate electrolyte levels and fluid balance and treat if necessary. Dialysis may be beneficial.
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Drug Interactions:
Amantadine / Toxic amantadine effects R/T renal excretion Angiotensin-converting enzyme inhibitors / Significant hyperkalemia Antihypertensives / Potentiated by triamterene Captopril / Risk of significant hyperkalemia Cimetidine / Bioavailability and clearance of triamterene Digitalis / Inhibited by triamterene Indomethacin / Risk of nephrotoxicity and acute renal failure Lithium / Chance of toxicity R/T renal clearance Potassium salts / Additive hyperkalemia Spironolactone / Additive hyperkalemia
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Capsules. Diuretic.

Adults, initial: 100 mg b.i.d. after meals; maximum daily dose: 300 mg.
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